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<p><b>Figure 1. QSM Flythrough -</b> A brief overview of the Quantitative Susceptibility Mapping (QSM) process. A mouse is scanned using a typical multi-echo gradient echo 3D MRI sequence and modeled for 3D analysis. QSM reconstructions allow for localized observation and quantification of super-paramagnetic iron oxide (SPIO) nanoparticles in specific areas of the subject.
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<p><b>Figure 2. QSM Heatmaps of the Liver - 1 Hour Post Nanoparticle Injection - </b> Representative image volumes of a mouse treated with lipopolysaccharide (LPS) to induce a sepsis-like condition, and injected with Leukocyte-Mimetic Nanoparticles (LMN) capable of specific delivery of SPIO nanoparticles to areas of acute inflammation. Control mice, not treated with LPS or injected with non-biospecific Non-Targeting Nanoparticles (NTN), are shown for comparison. QSM analysis shows considerable aggregation of SPIO in the liver in LPS positive cases injected with LMN, shown here as more intense colors over a T2* weighted greyscale navigational aid.
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<p><b>Figure 3. QSM Heatmaps of the Spleen - 1 Hour Post Nanoparticle Injection - </b> Representative image volumes of a mouse treated with lipopolysaccharide (LPS) to induce a sepsis-like condition, and injected with Leukocyte-Mimetic Nanoparticles (LMN) capable of specific delivery of SPIO nanoparticles to areas of acute inflammation. Control mice, not treated with LPS or injected with non-biospecific Non-Targeting Nanoparticles (NTN), are shown for comparison. QSM analysis shows considerable aggregation of SPIO in the spleen in LPS positive cases regardless of nanoparticle used, shown here as more intense colors over a T2* weighted greyscale navigational aid.
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<p><b>Figure 4. QSM Heatmaps of the Kidneys - 1 Hour Post Nanoparticle Injection - </b> Representative image volumes of a mouse treated with lipopolysaccharide (LPS) to induce a sepsis-like condition, and injected with Leukocyte-Mimetic Nanoparticles (LMN) capable of specific delivery of SPIO nanoparticles to areas of acute inflammation. Control mice, not treated with LPS or injected with non-biospecific Non-Targeting Nanoparticles (NTN), are shown for comparison. QSM analysis shows little to no precense of nanoparticles in the kidneys, regardless of nanoparticle used or the LPS treatment regimine, shown here as more intense colors over a T2* weighted greyscale navigational aid.
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<!-- <p><b>Figure 2. QSM Heatmaps of the Liver - 1 Hour Post Nanoparticle Injection - </b> Representative image volumes of a mouse treated with lipopolysaccharide (LPS) to induce a sepsis-like condition, and injected with Leukocyte-Mimetic Nanoparticles (LMN) capable of specific delivery of SPIO nanoparticles to areas of acute inflammation. Control mice, not treated with LPS or injected with non-biospecific Non-Targeting Nanoparticles (NTN), are shown for comparison. QSM analysis shows considerable aggregation of SPIO in the liver in LPS positive cases injected with LMN, shown here as more intense colors over a T2* weighted greyscale navigational aid.
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<!-- <p><b>Figure 2. LMN treated mice with inflammation induced by LPS 1 hour post-injection -</b> A representative image volume of a mouse treated with lipopolysaccharide <!-- (LPS) to induce a sepsis-like condition, and injected with Leukocyte-Mimetic Nanoparticles (LMN) capable of specific delivery of SPIO nanoparticles to areas of acute <!-- inflammation. QSM analysis shows considerable aggregation of SPIO in the liver, shown here as more intense colors over a T2* weighted greyscale navigational aid.
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<!-- <p><b>Figure 3. NTN treated mice with inflammation induced by LPS 1 hour post-injection -</b> A representative image volume of a mouse treated with lipopolysaccharide <!-- (LPS) to induce a sepsis-like condition, and injected with Non-Targeting Nanoparticles (NTN), a non-biospecific variant of LMN. QSM analysis shows considerably less <!-- aggregation of SPIO in the liver, shown here as more subdued colors in the liver region, with a grayscale T2* weighted navigational aid.
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labmembers:cancer_and_inflammation_quantification_using_targeted_contrast_agents_in_mr