<box 380px left grey> </box> | Figure 9. Engineering adeno-associated virus for systemic deliver to the brain as a gene therapy vehicle. Despite high density vasculature network in the brain (A), the majority of the therapeutic and diagnostic agents do not reach the brain due to the blood-brain-barrier (B). By inserting in the AAV capsid a peptide targeting BBB-transport, we aim to achieve a systemic delivery of AAV to the brain. |
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