https://www.jin-lab.org/ 2026-06-13T21:07:06+00:00 https://www.jin-lab.org/ https://www.jin-lab.org/lib/tpl/bootstrap3/images/favicon.ico text/html 2011-06-21T23:56:32+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:cancer_and_inflammation_quantification_using_targeted_contrast_agents_in_mr&rev=1308693392&do=diff text/html 2009-08-14T03:37:09+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:delivery_of_uan-nta_lfa-1_and_mac-1_cell_specific_targeting&rev=1250213829&do=diff Delivery of UAN-NTA LFA-1 and Mac-1 cell specific targeting INTRODUCTION The integrin lymphocyte function-associated antigen-1 (LFA-1) is expressed on the surface of leukocytes, and in the activated state promotes heterotypic adhesion to intercellular adhesion molecules on other immune cells. Stimulation of LFA-1 in the presence of Mg2+ and EGTA (or activating antibody CBRLFA-1/2) yields a conformational change, thereby creating a high affinity (HA) form of LFA-1 (1,9). text/html 2011-07-08T20:49:50+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:developing_nanoparticles_for_tumor_detection_and_therapy&rev=1310150990&do=diff [:labmembers:figure_1.png] Fig. 1. Synthesis and characterization of UAN. (A) UAN monomer is synthesized by covalently linking 2-HEMA, PEG, and glycerol propoxylate at 2:1:1 M ratio. (B) NTA-UAN is formed by cross-linking UAN monomers with AIBN and conjugation of NTA to PEG. NTA-UAN forms nanoparticles when suspended in aqueous solution. (C) TEM images of UAN nanoparticles after staining with uranyl acetate. Scale bar is shown. (D) The function and specificity of Ni-NTA on UAN nanoparticles wer… text/html 2011-02-15T02:04:09+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:group_photos&rev=1297731849&do=diff Lab Photos <box 320px left grey></box|Group photo, taken by Frank DiMeo on Oct 30, 2007> Lab Retreat August '08 Lab Retreat August '08-part2 Lab BBQ at Moonsoo's house July '08 Roisin's Farewell Dinner at Stella's and Madeleines May 2009 text/html 2022-01-19T23:22:48+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:index&rev=1642630968&do=diff Current Members Moonsoo M. Jin, Ph.D. Principal Investigator B.S.1997 Mechanical Engineering. SNU Sc.D. 2002 Mechanical Engineering. MIT Publications Postdoctoral Researchers Yanping Yang B.S. 2012 & Ph.D. 2017 College of Chemistry, Beijing Normal University Next-generation CAR T development text/html 2021-09-29T14:11:44+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:past&rev=1632917504&do=diff Past Members Postdoctoral associates Xuebo Hu Postdoc 2006-2011 Ph.D. 2006 Publications Taehyun Park Postdoc 2007-2011 Ph.D. 2007 Biochemistry and Biophysics Texas A&M Universiy Publications Xiaoling Gu Postdoc 2007-2011 Publications Roisin Owens Postdoc 2008-2011 Publications Keon Woo Kwon Postdoc 2009-2014 Ph.D. 2011 Mechanical engineering.SNU text/html 2010-02-12T22:02:10+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:polymer_nanoparticles_for_targeted_delivery_of_anti-inflammatory_drugs_and_rnai&rev=1266008530&do=diff UAN polymer nanoparticles for targeted delivery of anti-inflammatory drugs Immune cell adhesion has been implicated in both cancers and autoimmune diseases to emerge as a target for nanoparticle imaging and therapy. Prolonged inflammation at the tumor site contributes to angiogenesis and activation of leukocyte integrins. Amphiphilic urethane acrylate nonionomer (UAN) polymer nanoparticles have been equipped with activation-specific antibodies against leukocyte integrins to deliver a suite of d… text/html 2010-04-25T19:52:11+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:polymer_nanoparticles_for_targeted_delivery_of_magnetic_resonance_imaging_contrast_agents&rev=1272217931&do=diff Urethane Acrylate Polymer Nanoparticles for Targeted Delivery of Therapeutics and MRI Contrast Agents Previous work with amphiphilic urethane acrylate nonionomer (UAN) polymer nanoparticles yielded positive results; these particles proved to be fully functionalizable, and targeted delivery of therapeutics was a success. While UAN is entirely capable of encapsulating and delivering constrast agents (such as super paramagnetic iron oxide [SPIO]), this encapsulation compromises the ability to deli… text/html 2010-04-26T00:37:50+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:polymer_nanoparticles_for_targeted_delivery_of_therapeutics_and_magnetic_resonance_imaging_contrast_agents&rev=1272235070&do=diff Urethane Acrylate Polymer Nanoparticles for Targeted Delivery of Therapeutics and MRI Contrast Agents Previous work with amphiphilic urethane acrylate nonionomer (UAN) polymer nanoparticles yielded positive results; these particles proved to be fully functionalizable, and targeted delivery of therapeutics was a success. While UAN is entirely capable of encapsulating and delivering constrast agents (such as super paramagnetic iron oxide [SPIO]), this encapsulation compromises the ability to deli… text/html 2010-04-27T05:05:39+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:stabilized_immunoliposomes_for_targeted_drug_delivery&rev=1272337539&do=diff Stabilized Immunoliposomes for Targeted Drug Delivery Nwanyinma Nnodum (M.Eng 2009), Christopher Liu (M.Eng 2010) This project looks to address the problem of specific targeting of nanoparticles. In this case, unilamillar liposomes are prepared and surface modified with proteins for specific targeting such as integrin mAb. These nanoparticles are to then entrap siRNA, magnetic nanoparticles, and/or crystallized drugs to result in target stabilized nanoparticles (tsNPs) for delivery of therap… text/html 2010-07-08T19:34:34+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:the_structural_affinity_effect_of_mutational_n-glycosylation_on_vla-4_very_late_antigen_4_%CE%B14_1_integrin&rev=1278610474&do=diff The structural affinity effect of mutational N-glycosylation on VLA-4 (Very Late Antigen 4, α4β1) Integrin ---------- Introduction: Cancerous tumors often induce an inflammatory environment to promote the growth of new vascular tissue. In a typical response to such inflammations, the human immune system uses leukocytes cells to bind to the inflamed endothelial surface [1]. One of the key reactions that leukocytes use to bind to the endothelial cells is the interaction between leukocyte surfac… text/html 2009-09-02T07:16:07+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:thyroid_stimulating_hormone_receptor_superagonist_bound_liposomes_for_targeted_thyroid_cancer_therapy&rev=1251868567&do=diff Thyroid stimulating hormone receptor superagonist bound liposomes for targeted thyroid cancer therapy <box 596px left blue> </box> text/html 2009-08-14T03:01:35+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:tumor_targeting_nanoparticles&rev=1250211695&do=diff The UAN-NTA nanoparticle platform (NP) has been engineered for targeted delivery to organs involved in acute and chronic inflammation. Examining conformation -specific activity of integrins in YS2H and human cell lines will provide a method to probe endothelial interactions during lymphocyte migration in order to detect a trigger for inflammation. text/html 2010-03-16T02:52:01+00:00 Anonymous (anonymous@undisclosed.example.com) https://www.jin-lab.org/doku.php?id=labmembers:validation_of_iodinated_liposomes_as_computed_tomographic_contrast_agents&rev=1268704321&do=diff VALIDATION OF IODINATED LIPOSOMES AS COMPUTED TOMOGRAPHIC CONTRAST AGENTS Introduction Liposomes are composite structures made of phospholipids and may contain small amounts of other molecules. Membranes are the molecules that have a hydrophilic head group and a hydrophobic tail group, as a result the head is attracted to water, and the tail, which is made of a long hydrocarbon chain, is repelled by water.When membrane phospholipids are disrupted, they can reassemble themselves into tiny spher…